Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replaceing Neurod1 with Atoh7
نویسندگان
چکیده
Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replaceing Neurod1 with Atoh7 Chai-An Mao1, Jang-Hyeon Cho1, Jing Wang2, Zhiguang Gao1, Ping Pan1, Wen-Wei Tsai1, Xiuqian Mu3, Laura J. Frishman2 and William H. Klein1 1Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 2College of Optometry, University of Houston, Houston, TX 77204, USA. 3Department of Ophthalmology/Ross Eye Institute, New York State Center of Excellence in Bioinformatics and Life Sciences, and SUNY Eye Institute, University at Buffalo, Buffalo, NY 14203, USA. There was an error published inDevelopment 140, 541-551. Author Xiuqian Mu was inadvertently omitted. Mu provided a mouse line for the study and also provided important conceptual input into the work. The correct authors and affiliations are given above. The authors apologise to readers for this mistake. Development 140, 2849 (2013) doi:10.1242/dev.099549 © 2013. Published by The Company of Biologists Ltd CORRIGENDUM
منابع مشابه
Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.
The specification of the seven retinal cell types from a common pool of retina progenitor cells (RPCs) involves complex interactions between the intrinsic program and the environment. The proneural basic helix-loop-helix (bHLH) transcriptional regulators are key components for the intrinsic programming of RPCs and are essential for the formation of the diverse retinal cell types. However, the e...
متن کاملRewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5.
Retinal progenitor cells (RPCs) express basic helix-loop-helix (bHLH) factors in a strikingly mosaic spatiotemporal pattern, which is thought to contribute to the establishment of individual retinal cell identity. Here, we ask whether this tightly regulated pattern is essential for the orderly differentiation of the early retinal cell types and whether different bHLH genes have distinct functio...
متن کاملProper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6.
Timely generation of distinct neural cell types in appropriate numbers is fundamental for the generation of a functional retina. In vertebrates, the transcription factor Six6 is initially expressed in multipotent retina progenitors and then becomes restricted to differentiated retinal ganglion and amacrine cells. How Six6 expression in the retina is controlled and what are its precise functions...
متن کاملOverlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate
Retinal progenitor cells (RPCs) are programmed early in development to acquire the competence for specifying the seven retinal cell types. Acquiring competence is a complex spatiotemporal process that is still only vaguely understood. Here, our objective was to more fully understand the mechanisms by which RPCs become competent for specifying a retinal ganglion cell (RGC) fate. RGCs are the fir...
متن کاملBiasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2.
Within the developing vertebrate retina, particular subtypes of amacrine cells (ACs) tend to arise from progenitors expressing the basic helix-loop-helix (bHLH) transcription factor, Atoh7, which is necessary for the early generation of retinal ganglion cells (RGCs). All ACs require the postmitotic expression of the bHLH pancreas transcription factor Ptf1a; however, Ptf1a alone is not sufficien...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013